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Numerous studies have demonstrated that CD19, a B-cell specific antigen, is overexpressed in various B-cell neoplasms such as acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). The encouraging clinical efficacy of CD19-targeted chimeric antigen receptor (CAR) T-cell therapy in patients with CD19+ B-cell lymphomas has led to clinical and preclinical investigations of its potential use as a treatment for other CD19+ malignancies. In this article, the authors review CD19-targeted CAR T-cell therapy’s clinical and preclinical data and discuss the potential future role of CD19-targeted CAR T-cells as a treatment for other CD19+ malignancies.TEHRAN, Iran (AP) – Iran’s Supreme Leader Ayatollah Ali Khamenei says it is “not Islamic to slaughter women and children” and “we are committed to protecting them.”
His comments on Wednesday came after an attack by a suicide bomber targeted a military parade in Kabul, Afghanistan, killing at least 33 people and wounding at least 50, most of them soldiers.
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