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8,000 Classic Songs Of the World’s Music. Get It Right in Your Ear. Buy Music and Artist Top 25 Albums of All Time.Tacrolimus (FK-506) and roquinimex in syngeneic rat lung allotransplantation with immunosuppression by cyclosporine.
We investigated tacrolimus (FK-506) and roquinimex (ROQ), an immunosuppressant derived from polyoxin C (POC), in syngeneic heterotopic lung transplantation with low doses of cyclosporine. In 72 outbred Lewis rats, tracheal allotransplantation was performed, with the donor serving as the syngeneic graft in the left hemithorax. In the control group (n = 24), FK-506 was administered intravenously (0.3 mg/kg/day), beginning on the day of surgery. In the tacrolimus (TCL) group (n = 24), TCL was given intravenously (3 micrograms/kg/min) in addition to FK-506. In the ROQ group (n = 24), ROQ was administered intravenously (0.1 mg/kg/day) in addition to FK-506. Immunosuppression by cyclosporine (15 mg/kg) was begun on the first day of surgery and continued for 14 days. Successful transplantation was determined by histopathologic examination. Arterial pressures and left pleural effusion were measured. All 24 transplantations in the control group were successful. The survival rate of rats in the TCL group was 93.5% (22/24) and that of rats in the ROQ group was 83.3% (20/24). The mean values of pulmonary arterial pressure, pulmonary vascular resistance, and arterial blood O2 saturation in the TCL group were significantly lower (P a Skywalk gag gag
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