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From an ethical perspective, when patients are randomized to treatment groups based on information gained by retrospective analysis of other cohorts, there is significant loss of data and decreased power. Therefore, some groups consider it unethical to rely upon retrospective analysis (Gustafson and Modlin, [@B19]; O’Hara et al., [@B36]; Walther et al., [@B53]). Protocol designs to ensure unbiased sampling should be developed for each individual study, and statistical analyses used to minimize bias. With respect to the Pareto principle, the most powerful studies will be those that prospectively plan for unbiased sampling, and ensure that retrospective analysis is unbiased.
Author contributions {#s5}
====================
All authors listed, have made substantial, direct and intellectual contribution to the work, and approved it for publication.
Conflict of interest statement
——————————
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We gratefully acknowledge the following individuals for their assistance in cataloging the studies: Patricia S. McClure, Department of Medicine, Bristol-Myers Squibb, Princeton, NJ, USA; Bill Hinson, Carl C. Campbell II Medical Library, Duke University, Durham, NC, USA; Juan SanSes, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
^1^Data collected from:
[^1]: Edited by: Jean-Marc Cavaillon, Lyon Neuroscience Research Centre, France
[^2]: Reviewed by: Gem
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